LED lamp with mobile phone app, the emergence of a new breakthrough in diabetes treatment

The famous international academic journal "Science Translational Medicine" (Science Translational Medicine) website recently published the latest research results of East China Normal University researcher Ye Haifeng team. This is the first study through the implementation of intelligent mobile phone remote control over the treatment of diabetes, is expected to provide new ideas and new strategies for future clinical diagnosis and treatment of integration, accurate treatment of diabetes.

? left: This study author Ye Haifeng researcher; right: This study first author Shao Jiawei

In recent years, with the continuous innovation of mobile communication technology, the rapid development of intelligent mobile phone, has become a part of the medical action indispensable, has been applied in blood glucose monitoring. However, at present only for patients with diabetes diagnosis and detection function, can not achieve the treatment. Therefore, the team Ye Haifeng, East China Normal University School of life sciences skillfully combining synthetic biology and electronic engineering, developed a new intelligent diagnosis system in diagnosis and treatment of diabetes as a whole.

A new intelligent diagnosis system? In the diagnosis and treatment of diabetes as a whole

The system has two main features: first, the researchers through the mobile phone ECNU-TeleMed app remote control to control the brightness of far red gene expression; second, diabetic mouse white blood glucose level signal can be transformed into translation far red light brightness to the regulation of gene expression.

The design of intelligent mobile phone? Through the control of cell engineering of far red light response of semi automated to sketch of the treatment of diabetes

First of all, the concept of synthetic biology researchers used far red light control of gene expression were designed and synthesized the customized cell, the cell transformation in far red light irradiation, can produce any desired gene or drug protein, such as green fluorescent protein or insulin etc..

Far red? Regulation of gene expression control system design of the dynamic characteristics of graph and its regulation of gene expression

? far red spatiotemporal control of customized cells expressing green fluorescent protein. Can be achieved with far red light in the monolayer cell culture on any office. The cells above put the words ECNU hollow black paper, the far red cells activate the expression of green fluorescent protein

When the researchers showed far red control insulin customized cells transplanted into diabetic mice subcutaneously, diabetic mice given direct irradiation with far red light, can start the subcutaneous insulin producing cells, and play a good hypoglycemic effect. By using the method of treatment of diabetic rats, only light 2-4 hours a day, you can put the blood glucose maintained at the normal level and up to half a month.

The researchers used the combined multidisciplinary design method, further design and develop integrated intelligent control system of diagnosis and treatment of diabetes mellitus. Measured mice with blood glucose meter blood glucose levels, to the special intelligent controller via Bluetooth wireless transmission (Smart Controller) and intelligent mobile phone. When blood glucose levels are higher than the safe glucose threshold set in advance, the intelligent controller can light the LED complex containing hydrogel transplantation in mice, the customized cell (Hydroge LED), thereby triggering customized insulin producing cells or GLP-1, to lower blood sugar and maintain blood sugar stability. In addition, when the mobile phone display is abnormal, also can force the intelligent controller, optimize the scheme of treatment.

University of Wyoming molecular biologist Mark Gomelsky for the study of writing a commentary. He said, compared to the disk will be implanted in the body through the skin, wearing a LED bracelet can also achieve the same effect, but also more simple. However, the transformation of the cells still needs to be individually injected into the body, the transformation of cells need injections is still not clear how long.

Professor Gomelsky believes that after all the best method, East China Normal University technology may not be the treatment of type first diabetes, U.S. Food and Drug Administration (FDA) last year has just approved the first automatic insulin syringe. But he believes that this technology can be used to control drug cells to produce genetically modified distal, for the treatment of other diseases.

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